Sunday, August 30, 2015

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The Mutual UFO Network is holding a meeting this weekend for people who saw the object. The non-profit group says its investigators will begin taking statements at 1 p.m. on Saturday.

The Star-Telegram says this isn't the first time people in that part of the state have reported seeing strange things in the sky. Back in 1897, a Stephenville man told The Dallas Morning News that a 60-foot-long "aerial monster" landed on his farm.


Faster than a speeding bullet — and bigger than a Wal-Mart.

That's how residents near the west Texas town of Stephenville described an object they spotted in the sky one night last week.

Dozens of the town's residents — including a pilot and a police officer — said a UFO hovered over the farming community for about five minutes last Tuesday before streaking away into the night sky.

Pilot Steve Allen saw the object when he was out clearing brush off a hilltop near the town of Silden. Allen described the unidentified object as being an enormous aircraft with flashing strobe lights — and it was totally silent.

He said the UFO sped away at more than 3,000 mph, followed by two fighter jets that were hopelessly outmaneuvered. Allen said it took the aircraft just a few seconds to cross a section of sky that it takes him 20 minutes to fly in his Cessna.

The veteran pilot said the UFO, an estimated half-mile wide and a mile long, was "bigger than a Wal-Mart."

Military Dismisses Sighting

The Stephenville Empire-Tribune, which has written about the mysterious object, said about 40 people saw the thing — though some were too sheepish to admit the sighting until others came forward.

Police officer Leroy Gatin said he was walking to his car when he saw a red glow that reminded him of pictures he'd seen of an erupting volcano.

He said the object was suspended 3,000 feet in the air. Gatin said he was so awestruck that he called his son to come and see — but he didn't talk much about it until he saw a story about a UFO in the local paper.



Military officials, however, were skeptical. They said the residents are letting their imaginations run wild and passed it off as an optical illusion. They said it was likely nothing more than a reflection of sunlight on two airliners.

Officials at a nearby air force base also said their fighter pilots didn't chase down anything that night.

The incident was eerily similar to a UFO sighting a little more than a year ago at Chicago's O'Hare International Airport.

As many as 12 United Airlines employees spotted the object and filed reports with United.














































































































Combining a megapowerful magnet, multiple detectors, and carefully tweaked contrast, a new MRI technique developed at the National Institutes of Health (NIH) provides an unprecedented look at the fine structure of the brain. Using an MRI machine equipped with a magnet more than twice as powerful as one in an ordinary device, the researchers created a way to measure the magnetic field changes caused by tissue properties to optimize contrast in the image. They were also able to compensate for the magnetic field fluctuations created by the patients’ breathing. The technique revealed never-before-seen patterns in the white matter and gray matter of the human brain.

Picking up on such differences may help researchers look more deeply into the brain’s subdivisions, allowing them to map it in greater detail. It may also bring about advances in diagnosing diseases like Alzheimer’s and multiple sclerosis, both of which involve abnormal iron accumulation in the brain. For patients, the new technique may mean that “you could more accurately—and maybe earlier—diagnose a disease,” says NIH physicist Jeff Duyn.
Only eight MRI machines this powerful exist in the United States, and all are housed in research, rather than clinical, settings. Each costs around $5 million, and that’s before the expense of setup—which includes installing 380 tons of shielding material to prevent every metal object in the building from being sucked into the magnet.


Chinese researchers announced (pdf) in March that they had created glass that can be bent into right angles without shattering. But this isn’t glass as we know it: The new glass is opaque, twice as strong as window glass, and made of metal.

As solids, metals have an orderly atomic structure; in liquid metals, the arrangement becomes random, as in glass. To create metallic glass, scientists supercool liquid metals, effectively “freezing” the random array in place. These bulk metallic glasses, or BMG, are two to three times stronger than the crystalline form of the metals.

Superstrong BMG has already been used in the manufacture of high-tech golf clubs and tennis rackets; in 2001, the collector on NASA’s Genesis spacecraft, which caught particles from the solar wind, was made of BMG.
But since the 1980s, when scientists began making BMG, the materials have exhibited a fatal flaw. Paradoxically, the stronger they are, the more vulnerable they are to cracks, says Wei Hua Wang, a physicist who helped develop the new glass at the Chinese Academy of Sciences. A tiny fracture in the original type of BMG spreads quickly and becomes catastrophic.



To create a glass that is both strong and flexible, Wang and his colleagues altered an existing BMG recipe, combining zirconium, copper, nickel, and aluminum. Realizing that small changes in the metal mixture would lead to large variations in brittleness, they sought a combination that would keep cracks from spreading. “The plasticity of the glass is very sensitive to the composition,” Wang explains.

After two years, the scientists produced bendable BMG. It contains hard areas of high density surrounded by soft regions of low density. The result: When a crack begins in one place, it dissipates quickly in the surrounding regions, leaving the whole flexible.

Believe it or not, there are some folks who make a living as professional guinea pigs in tests of experimental drugs. Some question whether testing that relies on frequent lab fliers takes advantage of poor people or compromises the quality of the data.

In a recent issue of the New Yorker, bioethics professor Carl Elliot, from the University of Minnesota, details how early drug safety testing has become more of a business transaction than a scientific endeavor in an article called “Guinea-Pigging.” He’ll also be exploring the topic as part of a book he’s writing on corruption, money and medicine that he expects to be called “White Coat, Black Hat” and to be published next year. We asked Elliot, who is on sabbatical in New Zealand, a few questions via e-mail. Here are the highlights of the long-distance conversation:

How does professional guinea-pigging affect the data on experimental drugs?

What I heard about most often was subjects stretching the truth about their medical histories in order to get into high-paying studies. That seems to be fairly common. I don’t know what kind of impact it has on the results, but it shouldn’t be terribly shocking. We have a safety testing system where subjects don’t have any stake in the results of the study, where they don’t really trust the research sponsors, and where they don’t believe they are going to get access to the drugs that are developed by the studies. If poor people are being asked to test drugs for the benefit of rich people, then we shouldn’t be surprised if the poor people are not always perfectly compliant.

Should we change the system to discourage professional guinea-pigging?

Well, one thing that worries me is the damage that all these studies could be doing to the long-term health of the guinea pigs. They are mostly uninsured, so they are in no position to get regular medical care, and nobody else has any financial interest in monitoring their health.

Payment itself is a real dilemma. New drugs need to be tested for safety, and I can’t imagine that many people will volunteer to test the safety of new drugs for free anymore, especially if it means checking into a testing site for three weeks to undergo invasive medical procedures. But it feels unfair to put the burden on poor people who are driven to volunteer at these testing sites because they can’t get any other kind of work. If we are going to have a payment-based system, we need to make sure that poor subjects are not being exploited.

What changes are needed for safety’s sake?

Apart from watchdog groups like Circare, which operate on a shoestring budget, and investigative reporters, there really are very few people outside the research enterprise watching these studies. Formal oversight has been outsourced to for-profit IRBs [institutional review boards], which are paid by the companies doing the research, and which mainly look at studies on paper. The complaints I often heard about from guinea pigs were conditions on the ground that IRBs have never really thought much about. I don’t think it ever occurred to an IRB to ask SFBC [SFBC International, a company that owned the largest drug-testing site in North America] whether they were testing drugs on undocumented immigrants in a dilapidated motel. Some testing sites have procedures that are not really dangerous, but which are uncomfortable or degrading, like requiring subjects to have a rectal exam whether or not it is relevant to the study. And of course, somebody needs to make sure that researchers who are crooked or incompetent are not allowed to keep doing research. http://louis-j-sheehan.biz/page1.aspx




What can or should be done for participants who are injured or suffer other side effects during a trial?

The very least that can be done is to guarantee that they will get medical care without being stuck with the bill. As things stand now, guinea pigs can’t even count on that. That’s not just a problem with industry studies. Even subjects in federally sponsored trials in universities don’t get that guarantee. Robert Steinbrook published a piece in the New England Journal of Medicine a couple of years ago showing that only 16% of academic health centers in the U.S. provided free care to injured subjects, and none of them compensated subjects for pain and suffering.

Where do you see this process of human subject testing headed?

It’s heading overseas to the developing world. It’s less expensive and the oversight is less rigorous. I think the problems will be the same as here, only more so.

The sequel is out there.

The conspiracy theories will not be.

Ten years after the first film and six years after the show went off the air, The X-Files returns to theaters with Fox Mulder, Dana Scully — and a lot riding on the bet that fans want more of the FBI's paranormal-investigating agents.

The film, which remains without a formal title, will dump the long-running "mythology" plotline — that aliens live among us and are part of a colonizing effort — that made it one of the most popular television shows in the late 1990s but ultimately drove away some viewers who found it too complex and ambiguous.

"We spent a lot of time on (the mythology) and wrapped up a lot of threads" when the show went off the air in 2002, says Chris Carter, creator of the series and director of the new movie. "We want a stand-alone movie, not a mythology conspiracy one."

That will come as welcome news to fans of the show's stand-alone episodes, which included cults, ghosts, psychics and ancient curses.

Carter refuses to divulge any plot points of the movie, but says he wanted to make the film immediately after the show ended. A contractual dispute with 20th Century Fox kept it on the shelf until the case was settled out of court.

He says the delay may turn out to be a blessing.

"There's a whole audience I want to introduce X-Files to," Carter says. "There were kids who couldn't watch it on TV because it was too scary. Now they're in college. I wanted a movie that everyone could go to."

Whether they will could be a test of the show's legacy, says Blair Butler of the G4TV network, which caters to video-game enthusiasts and science-fiction fans.

"At its strongest, it had really creepy stand-alone episodes," she says. "They turned it into a great franchise. But a lot of years have passed. We'll see if it's fallen off the radar."

She says the film could benefit from an ironic twist: the Writers Guild strike.

"I think it could be a sort comfort food for the people who loved how original the show was and aren't seeing original TV now," she says.

But Carter believes they'll be drawn by something else: the show's stars, David Duchovny and Gillian Anderson.

"For me, The X-Files has always been a romance," he says. "They had an intellectual romance that's very rare and restrained compared to so many relationships on TV. I think that's what appealed most to the fans. And they're back."


People have been trying to figure out why we sleep for almost as long as we have been conscious of being awake, tossing and turning in the dark.

After a few restless nights, most of us can't even think straight. We are less able to make sense of problems, make competent moral judgments or retain what we learn, even though studies show our brain cells fire more frenetically to overcome the lack of sleep. Lose too much sleep and we become reckless, emotionally fragile, and more vulnerable to infections and to diabetes, heart disease and obesity, recent research suggests.



We spend a third of our lives asleep, yet no one really knows why. We do know that people simply don't perform as well when they don't sleep enough.
How sleepy are you?
The Epworth Sleepiness Scale can help you rate how likely you are to doze off or fall asleep.
The American Academy of Sleep Medicine and the National Sleep Foundation offer general information about sleep and sleep disorders. The National Institute of Neurological Disorders and Stroke also offers a detailed rundown on the basics of sleep.
New scientific findings about the biology of sleep are highlighted at Sleep Research Online



Bedside Reading
The Society for Neuroscience offers these Brain Briefings on sleep and learning, insomnia and sleep deficits.
For bedside reading about sleep, Stanford University researcher William Dement, founder of the world's first sleep disorder clinic, and science writer Christopher Vaughan outline cures for "a sleep-sick society" in The Promise of Sleep: A Pioneer in Sleep Medicine http://louis-j-sheehan.net



Yet scientists probing the purpose of sleep are still largely in the dark. "Why we sleep at all is a strange bastion of the unknown," said sleep psychologist Matthew Walker at the University of California in Berkeley.

One vital function of sleep, researchers argue, may be to help our brains sort, store and consolidate new memories, etching experiences more indelibly into the brain's biochemical archives.

Even a 90-minute nap can significantly improve our ability to master new motor skills and strengthen our memories of what we learn, researchers at the University of Haifa in Israel reported last month in Nature Neuroscience. "Napping is as effective as a night's sleep," said psychologist Sara Mednick at the University of California in San Diego.

Moreover, slumber seems to boost our ability to make sense of new knowledge by allowing the brain to detect connections between things we learn.

In research published last April in the Proceedings of the National Academy of Sciences, Dr. Walker and his collaborators at the Harvard Medical School tested 56 college students and found that their ability to discern the big picture in disparate pieces of information improved measurably after the brain could, during a night's sleep, mull things over.

It is these patterns of meaning -- the distilled essence of knowledge -- that we remember so well. "Sleep helps stabilize memory," said neurologist Jeffrey Ellenbogen, director of the sleep medicine program at Massachusetts General Hospital.

The erratic biorhythms of sleep and behavior are intertwined everywhere in nature. Socially active fruit flies need more sleep than loner flies, and even zebra fish can get insomnia.

Sleep is controlled partly by our genes. The difference between those of us who naturally wake at dawn and night owls who are wide-eyed at midnight may be partly due to variations in a gene named Period3, which affects our biological clock. Variations in that gene also make some people especially sensitive to sleep deprivation, scientists at the U.K.'s University of Surrey recently reported.



How much sleep do you need? And how much do you actually get? Tell us about your sleep habits in an online forum12.

For many of us, though, sleeplessness is a self-inflicted epidemic in which lifestyle overrides basic biology. "In this odd, Western 24-hour-MTV-fast-food generation we have created, we all feel the need to achieve more and more. The one thing that takes a hit is sleep," Dr. Walker said. On average, most people sleep 75 minutes less each night than people did a century ago, sleep surveys record.

Yet, rarely have so many millions of drowsy people been trying so hard to secure some shut-eye, spending billions on sleep aids. By one estimate, pharmacists filled 49 million prescriptions for sleep drugs last year. Even so, we think we sleep more than we actually do, according to Arizona State University scientists. They recorded how long 2,100 volunteers actually slept each night and compared that with how long the people reported they had slept. Most people overestimated their sleep by about 18 minutes, the scientists found.

Psychologists Jeffrey Ellenbogen at Harvard's Mass General Hospital and Matthew Walker at UC/Berkeley found that sleep boosts our ability to make sense of new knowledge by allowing the brain to detect connections and patterns between things we learn. They reported their findings recently in The Proceedings of the National Acemdy of Sciences.

The consequences of too little sleep can be dire. Almost half of all heavy-truck accidents can be traced to driver fatigue, while decisions leading to the Challenger space-shuttle disaster, the Chernobyl nuclear-reactor meltdown and the Exxon Valdez oil spill can be partly linked to people drained of rest by round-the-clock work schedules. Weary doctors make more serious medical errors, while sleepy airport baggage screeners make more security mistakes, researchers reported at the Associated Professional Sleep Societies.

All told, the frayed tempers, short attention spans and fuzzy thinking caused by sleep deprivation may cost $15 billion a year in reduced productivity, the National Commission on Sleep Disorders Research estimated.

The expectation of a nap, however, is by itself enough to measurably lower our blood pressure, researchers at the Liverpool John Moores University in England reported in October in the Journal of Applied Physiology.


Indeed, regular nappers -- working men who took a siesta for 30 minutes or more at least three times a week -- had a 64% lower risk of heart-related death, researchers at the University of Athens reported last February in the Archives of Internal Medicine.

"All of the things we are proving about sleep and the brain are things that your mother already knew decades ago," Dr. Walker said. "We are putting the science and the hard facts behind it."

Scientists have taken a key step toward understanding the cause of prostate cancer, finding that a combination of five gene variants sharply raises the risk of the disease. Added to family history, they accounted for nearly half of all cases in a study of Swedish men.

The discovery is remarkable not just for the big portion of cases it might explain, but also because this relatively new approach -- looking at combos rather than single genes -- may help solve the mystery of many complex diseases.

It also might lead to a blood test to predict who is likely to develop prostate cancer. These men could be closely monitored and perhaps offered hormone-blocking drugs like finasteride to try to prevent the disease.

The Swedish results must be verified in other countries and races, where the gene variants, or markers, may not be as common. Researchers already have plans to look for them in U.S. men. Unfortunately, the markers do not help doctors tell which cancers need treatment and which do not -- they turned out to have nothing to do with the aggressiveness of a tumor, only whether a man is likely to develop one.



The study was led by doctors at Wake Forest University in Winston-Salem, N.C., and involved Johns Hopkins University in Baltimore and the Karolinska Institute in Stockholm. Results were published online by the New England Journal of Medicine.

It involved 2,893 men with prostate cancer and 1,781 similar men who did not have the disease. Sweden was chosen because the population is so ethnically similar and well suited to gene studies.
        




























































































Figuring Out Fido
To better understand man's best friend, Hungarian scientists are working on computer software that analyzes dog barks. It could help humans recognize basic canine emotions, Hungarian ethologist Csaba Molnar told Reuters. Mr. Molnar and his colleagues at Budapest's ELTE University have tested software which distinguishes the emotional reaction of 14 dogs of the Hungarian Mudi herding breed to six situations: being alone, seeing a ball, fighting, playing, encountering a stranger or going for a walk. "A possible commercial application could be a device for dog-human communication," the scientist added. The iDog, perhaps?

        
        
John McCain is looking for deep support from his military brethren to win South Carolina -- the state that ended his presidential bid eight years ago.

Mr. McCain sees a big difference this time. "We were not in a war in 2000," he said here yesterday. "I'm the only one who is really qualified to be commander-in-chief."

After conceding a loss Tuesday night in Michigan's Republican primary, the Arizona senator turned his attention to South Carolina's significant population of active-duty military and veterans.


"I have long admired the deep patriotism of the people of this state," the Navy veteran said in Charleston. "So many of your sons and daughters risk their lives today to keep the rest of us safe, as so many South Carolinians have done in past wars," he said.

The Republican race for president arrives in South Carolina in some disarray. "It is a chessboard extraordinaire," with three candidates having won primaries and no clear leader, said Republican strategist Tony Fabrizio, who isn't affiliated with any campaign.

Mr. McCain is hoping to nose ahead of the pack with a win here Saturday, much of it with the support of the state's sizable military presence. The only one of the major candidates who has served in the military, he upped the ante yesterday by predicting a South Carolina victory, something he declined to do before the Michigan primary.



"We will win South Carolina," he said at a campaign event in Greenville. His aides say a victory here would propel him through Florida's Jan. 29 contest and into the all-important "Super Tuesday" primaries Feb 5. They aren't saying what it means if he loses.

Mr. McCain lost South Carolina in 2000 after outside groups made what turned out to be wild accusations about the senator's integrity on a host of issues, including his military record. This time Mr. McCain has a rapid-reaction force, including many veterans, to refute such attacks.

That force was put into use Tuesday when a mailer arrived in some South Carolina homes accusing Mr. McCain of distorting his record as a prisoner of war in North Vietnam. Orson Swindle, a close McCain ally and former prisoner of war, dismissed the mailer as coming from "conspiracy-theory people" and saying such attacks on Mr. McCain aren't new. "It's slander, it affects voters, obviously," he said. "It's a bit crazy, too."


The military vote is "very important," senior McCain adviser Steve Schmidt said yesterday. "John McCain speaks the language of the men and women who serve in the military." Mr. Schmidt and other campaign aides said the military vote alone isn't enough to win, but it is a key part of his strategy.

McCain campaign aides are hoping Mr. McCain and his rivals -- Mike Huckabee, Mitt Romney and Fred Thompson -- divide the evangelical vote, leaving the state's sizable population of military and independent voters to Mr. McCain.



Mr. Huckabee is seen as Mr. McCain's main rival. The Southern Baptist minister has emerged as the favorite of the state's Christian conservatives, especially since he upset Mr. Romney to win the Iowa caucuses. Mr. Romney split the state's party establishment early on with Mr. McCain but has yet to gain traction among rank-and-file Republicans suspicious of his Mormon faith and social-issue flip-flops. Mr. Thompson entered the Republican race late and counted on Christian conservatives' support -- only to see them suddenly flock to Mr. Huckabee amid his Iowa success.

The McCain team has reason for optimism on the military front. Veterans carry heavy weight in South Carolina's Republican politics. They were 14% of the adult population in 2000, according to the Census Bureau, but 27% of voters in the Republican primary, according to exit polls. Though Mr. McCain lost South Carolina to George W. Bush in 2000 by 53% to 42%, he won the veteran vote 48% to 47%, according to exit polls.



South Carolina is home to 400,000 veterans, according to the Census Bureau. It has high numbers of military personnel stationed in-state and abroad. Almost 29,000 active-duty soldiers claim the state as their legal residence, making up about 1% of its population -- only nine states have a higher percentage. And there are 66,000 soldiers stationed here, constituting about 2% of its adult population, greater than all but eight states.

At campaign stops yesterday, Mr. McCain hammered home his pro-military message about caring for the troops, resolving the Iraq war and improving veterans' health care. He spoke glowingly of the 2,000 South Carolina National Guard and reserve troops who are in Afghanistan and called out veterans in the audience.

And as he often does on the stump, he read a quote from George Washington about the importance of looking after veterans. "The willingness with which our young people are likely to serve in any war, no matter how justified, will be directly proportional as to how they perceived the veterans of earlier wars were treated and appreciated by their country," Mr. McCain said, echoing President Washington.

That message plays well with voters such as Gary Wells, 73 years old, a Greenville resident and veteran who said he served as a Russian linguist in military intelligence in Berlin during the Cold War. He came to a McCain event in Greenville yesterday undecided between Mr. McCain and Mr. Romney. But he liked what Mr. McCain "said about the veterans and the military," particularly the senator's plan to give veterans an insurance card for routine visits to be used at any doctor, rather than having to go to Veterans Administration hospitals, he said. Mr. Wells calls VA hospitals "really horrible."

The Arizona senator made his first stop here after his New Hampshire triumph at the Citadel military college last week. His last major public event before the primary is scheduled to be Friday evening on the decommissioned aircraft carrier U.S.S. Yorktown, in Mount Pleasant, S.C.

Mr. McCain's surrogates also spread the military message yesterday. "Let's make sure the military is well-led by somebody who understands their world," said Republican South Carolina Sen. Lindsey Graham.

Cindy McCain, the senator's wife, talked about their two sons who are serving, one at the Naval Academy, the other in the Marines. At a McCain townhall meeting in Spartanburg, S.C., Mrs. McCain said she supported her husband's run, in part because "it's about my children being safe, my sons particularly, your sons and daughters...that they serve with honor and dignity and come home with dignity."

Veterans and their spouses fill the seats at almost every McCain event, donning blue "Veterans for McCain" stickers. Yet even they acknowledge their ranks are only part of what will make up a McCain victory. "John McCain has a very loyal base among the veterans," said John McGraw, 65, who served in the Navy's River Patrol Force in Vietnam. Speaking before a McCain event yesterday here in Greenville, he said the military vote is "not enough. He has to get other individual Republicans."



"We hear that phone calls are being made. We will not let it go this time," John McCain told reporters, in reference to calls like those made to South Carolina voters from a group calling itself Vietnam Veterans Against McCain, which accuses the Republican presidential candidate, senator and former prisoner of war of selling out fellow POWs to save himself, the New York Times reports. Another group called Common Sense Issues, which supports rival candidate Mike Huckabee, has begun making what it said were a million automated calls to households in South Carolina telling voters that Mr. McCain "has voted to use unborn babies in medical research," the Times adds. (Mr. Huckabee's campaign says it has no ties to the group.) Burned in the 2000 South Carolina primary by one of the most notorious smear campaigns in recent American politics -- which contributed to his loss to President Bush -- Mr. McCain this time seems more determined to fight back aggressively and is deploying a "Truth Squad" in the state with the help of South Carolina's Republican political establishment.





The effectiveness of 12 popular antidepressants has been exaggerated by manufacturers' selective publication of favorable results, researchers asserted in a new review of unpublished data that were submitted to the Food and Drug Administration.

As a result, the review concludes, doctors and patients are getting a distorted view of the effectiveness of blockbuster antidepressants like Wyeth's Effexor and Pfizer Inc.'s Zoloft. The review was published in the New England Journal of Medicine.


A review of research submitted to the FDA:
• Of 74 studies reviewed, 38 were judged to be positive by the FDA. All but one were published, researchers said.
• Most of the studies found to have negative or questionable results were not published, researchers found.
Source: The New England Journal of Medicine

Since the overwhelming amount of published data on the drugs show they are effective, doctors unaware of the unpublished data are making inappropriate prescribing decisions that aren't in the best interest of their patients, according to researchers led by Erick Turner, a psychiatrist at Oregon Health & Science University. Sales of antidepressants total about $21 billion a year, according to IMS Health.

Wyeth and Pfizer declined to comment on the study results. Both companies said they had committed to disclose all study results, although not necessarily in medical journals. GlaxoSmithKline PLC, maker of Wellbutrin and Paxil, said it has posted the results of more than 3,000 trials involving 82 medications on its Web site, and also has filed information on 1,060 continuing trials at a federal government Web site.

Schering-Plough Corp., whose Organon Corp. unit markets Remeron, and Eli Lilly & Co., which makes Prozac, said their study results were indeed published -- not individually, but as part of larger medical articles that combined data from more than one study at a time. The New England Journal study counted a clinical trial as published only if it was the sole subject of an article. "Lilly has a policy that we disclose and publish all the results from our clinical trials, regardless of the outcomes from them," a Lilly spokeswoman said.

Pharmaceutical companies are under no obligation to publish the studies they sponsor and submit to the FDA, nor are the researchers they hire to do the work. The researchers publishing in the New England Journal were able to identify unpublished studies by obtaining and comparing documents filed by the companies with the FDA against databases of medical publications.

"There is no effort on the part of the FDA to withhold or to not post drug review documents," an FDA representative said. For newer drugs, information is posted online "as soon as possible." Older documents aren't always available online and efforts to add those files to the Web are slowed by "a lack of resources," the agency said, acknowledging that there is a backlog in complying with records requests.

A total of 74 studies involving a dozen antidepressants and 12,564 patients were registered with the FDA from 1987 through 2004. The FDA considered 38 of the studies to be positive. All but one of those studies was published, the researchers said.

The other 36 were found to have negative or questionable results by the FDA. Most of those studies -- 22 out of 36 -- weren't published, the researchers found. Of the 14 that were published, the researchers said at least 11 of those studies mischaracterized the results and presented a negative study as positive.

Five Trials

For example, Pfizer submitted five trials on its drug Zoloft to the FDA, the study says. The drug seemed to work better than the placebo in two of them. In three other trials, the placebo did just as well at reducing indications of depression. Only the two favorable trials were published, researchers found, and Pfizer discusses only the positive results in Zoloft's literature for doctors.

One way of turning the study results upside down is to ignore a negative finding for the "primary outcome" -- the main question the study was designed to answer -- and highlight a positive secondary outcome. In nine of the negative studies that were published, the authors simply omitted any mention of the primary outcome, the researchers said.

The resulting publication bias threatens to skew the medical professional's understanding of how effective a drug is for a particular condition, the researchers say. This is particularly significant as the growing movement toward "evidence-based medicine" depends on analysis of published studies to make treatment decisions.

Colleagues' Questions

Dr. Turner, who once worked at the FDA reviewing data on psychotropic drugs, said the idea for the study was triggered in part by colleagues who questioned the need for further clinical drug trials looking at the effectiveness of antidepressants.



"There is a view that these drugs are effective all the time," he said. "I would say they only work 40% to 50% of the time," based on his reviews of the research at the FDA, "and they would say, 'What are you talking about? I have never seen a negative study.'" Dr. Turner, said he knew from his time with the agency that there were negative studies that hadn't been published.

The suppression of negative studies isn't a new concern. The tobacco industry was accused of sitting on research that showed nicotine was addictive, for instance. The issue has come up before notably with antidepressants: In 2004, the New York state attorney general sued GlaxoSmithKline for alleged fraud, saying it suppressed studies showing that the antidepressant Paxil was no better than a placebo in treating depression in children. Glaxo denied the charge and eventually settled with the attorney general. The company later posted on its Web site the full reports of all of the studies of Paxil in children.

But publication of negative studies is an issue that cuts across all medical specialties. And it has engendered some strong reactions in the medical-research world: To make it harder to conceal negative study findings, an association of medical journal editors began requiring in 2005 that clinical trials be publicly disclosed at the outset to be considered for publication later. The system isn't foolproof, since manufacturers often run exploratory studies without registering them and can selectively disclose favorable results. The rule only applies to studies intended for publication in a medical journal.


Some studies that don't eventually get published are registered with online trial registries, including the federal government's www.clinicaltrials.gov. Nonetheless, many studies still aren't being registered or reported, says Kay Dickersin, the director of the Center for Clinical Trials at the Johns Hopkins Bloomberg School of Public Health. "We need something more meaningful," she said. "The average person has no idea that www.clinicaltrials.gov is not comprehensive."

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